论文快速发表网

社科类论文科技类论文医学类论文管理类论文教育类论文农林类论文新闻类论文建筑类论文文艺类论文法学类论文

EI Compendex Source List（2022年1月） EI Compendex Source List（2020年1月） EI Compendex Source List（2019年5月） EI Compendex Source List（2018年9月） EI Compendex Source List（2018年5月） EI Compendex Source List（2018年1月）中国科学引文数据库来源期刊列 CSSCI(2017-2018)及扩展期刊目录 2017年4月7日EI检索目录（最新） 2017年3月EI检索目录最新公布北大中文核心期刊目录 SCI期刊（含影响因子）

本站服务项目浅谈青年教师如何开展教科研大学青年教师如何处理教学和科

论文范文

Recent Advances in the Development of Vaccines for Diabetes, Hypertension, and Atherosclerosis 时间:2018-09-29 22:30 来源:未知作者:admin 点击: 次 Abstract:Vaccines are commonly used in the prevention of infectious diseases. The basic principle of vaccination is to use specific antigens, endogenous or exogenous to stimulate immunity against the specific antigens or cells producing them. Autoantigen or oligo vaccination has been used for disease animal models. More recently humanized monoclonal antibodies have been successfully used for the treatment of neoplastic disorders or familial hypercholesterolemia. Humanized monoclonal antibody therapy needs repeated injection, and the therapy is expensive. Therapeutic vaccination can lead to persistent immunized or immune tolerant against the therapeutic molecule(s) or site. However, immunization against those endogenous substances may also elicit persistent autoimmune reaction or destruction that do harm to health. Therefore, rigorous studies are needed before any clinical application. In this review, we briefly reviewed vaccines used in protection against common metabolic diseases including atherosclerosis, hypertension, and diabetes mellitus.
1. Introduction
Over the past decades, the lifespan of a human being increased significantly; however, affluence and aging-related metabolic diseases (diabetes, hypertension, dyslipidemia, atherosclerosis, etc.) increased too. Metabolic disease usually results from the abnormality of normal chemical processes. With advances in understanding the mechanism of these metabolic disorders, great progress has been made in finding new drugs to correct the disease pathophysiology. As metabolic diseases are always associated with an unhealthy lifestyle or in some are associated with hereditary abnormalities, lifelong medication is needed and frequently results in low medication compliance. Therefore, scientists have screened the sea of molecular targets in trying to correct the pathophysiological process in a new way. More recently, trials of a humanized monoantibody, inhibiting proprotein convertase subtilisin/kexin type 9 (PCSK9) given 4 times over a period of one month showed a significantly long-term effect in decreasing low-density lipoprotein (LDL) cholesterol and a significant decrease in atherosclerotic events [1]. However, monoclonal antibodies are expensive and require repeated injection. Therefore, the replacement of monoclonal antibody therapy by vaccines might be an excellent alternative. Vaccine is a special biological preparation that elicits the adaptive immunity to defend against specific antigens. Although vaccine was originally designed to prevent or ameliorate infectious disease, it could also be used as a useful tool to provide a long-term antibody by eliciting adaptive immune responses. Recently, the vaccination of metabolic disease has made a great progress, especially in the treatment of dyslipidemia, atherosclerosis, diabetes mellitus, and hypertension.